Helen E. Collins Laboratory - Mitochondrial Morphology and Mitophagy

Journal article

Helen E Collins, Mariame S. Kane, Silvio Litovsky, Victor Darley-Usmar, Martin E. Young, John C. Chatham, Jianhua Zhang
Frontiers in Aging, 2021

Semantic Scholar DOI

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APA Click to copy
Collins, H. E., Kane, M. S., Litovsky, S., Darley-Usmar, V., Young, M. E., Chatham, J. C., & Zhang, J. (2021). Mitochondrial Morphology and Mitophagy in Heart Diseases: Qualitative and Quantitative Analyses Using Transmission Electron Microscopy. Frontiers in Aging.

Chicago/Turabian Click to copy
Collins, Helen E, Mariame S. Kane, Silvio Litovsky, Victor Darley-Usmar, Martin E. Young, John C. Chatham, and Jianhua Zhang. “Mitochondrial Morphology and Mitophagy in Heart Diseases: Qualitative and Quantitative Analyses Using Transmission Electron Microscopy.” Frontiers in Aging (2021).

MLA Click to copy
Collins, Helen E., et al. “Mitochondrial Morphology and Mitophagy in Heart Diseases: Qualitative and Quantitative Analyses Using Transmission Electron Microscopy.” Frontiers in Aging, 2021.

BibTeX Click to copy

@article{helen2021a,
  title = {Mitochondrial Morphology and Mitophagy in Heart Diseases: Qualitative and Quantitative Analyses Using Transmission Electron Microscopy},
  year = {2021},
  journal = {Frontiers in Aging},
  author = {Collins, Helen E and Kane, Mariame S. and Litovsky, Silvio and Darley-Usmar, Victor and Young, Martin E. and Chatham, John C. and Zhang, Jianhua}
}

Abstract

Transmission electron microscopy (TEM) has long been an important technique, capable of high degree resolution and visualization of subcellular structures and organization. Over the last 20 years, TEM has gained popularity in the cardiovascular field to visualize changes at the nanometer scale in cardiac ultrastructure during cardiovascular development, aging, and a broad range of pathologies. Recently, the cardiovascular TEM enabled the studying of several signaling processes impacting mitochondrial function, such as mitochondrial fission/fusion, autophagy, mitophagy, lysosomal degradation, and lipophagy. The goals of this review are to provide an overview of the current usage of TEM to study cardiac ultrastructural changes; to understand how TEM aided the visualization of mitochondria, autophagy, and mitophagy under normal and cardiovascular disease conditions; and to discuss the overall advantages and disadvantages of TEM and potential future capabilities and advancements in the field.